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Molecular Epidemiology of HIV-1 Subtypes in India:
Origin & Evolutionary History of the Predominant Subtype C
Background:
• IndiahasthethirdlargestHIV-1epidemicwith2.4 million infected individuals.
• Molecular epidemiological analysis has identified the predominance of HIV-1 subtype C (HIV-1C).
• Bloodsampleswerecollectedfrom168HIV-1 seropositive subjects from 7 different states.
Ref. Ujjwal Neogi et.al. PLoS One June 2012, Vol. 7. Issue 6
Contd.
Duru Shah
Contd.
• HIV-1 subtypes were determined using two or three genes, gag, pol, and env using several methods.
• Ahighprevalence(10%)ofuniquerecombinant forms (BC and A1C) was observed when two or
three genes were used instead of one gene (p,0.01; p = 0.02, respectively).
• The Indian HIV-1C epidemic originated around 40 years ago from a single or few genetically
related African lineages, and since then largely evolved independently.
Ref. Ujjwal Neogi et.al. PLoS One June 2012, Vol. 7. Issue 6
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PRECONGRESS COURSE 12 I VIENNA, AUSTRIA – 23 JUNE 2019 63
