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Safety – Toxicity
• Data are limited
• Possible side effects of oral progestins:
• Thromboembolism
• Mood alterations
• Headaches
• Weight gain
• Increased risk of breast cancer
Balance between efficacy & toxicity
Ushijima K, et al, J Clin Oncol 2007; 25:2798
Follow‐up
• Assessment of response at 6 months with D&C, with or without hysteroscopy and imaging
• Complete response (CR) is defined as the absence of any form of hyperplasia
• BMI > 25 is associated with failure in achieving CR to progestin treatment
Kim MK, et al, Gynecol Oncol 2013; 130: 470–473 Park JY, et al, Eur J Cancer 2013; 49:868 Ushijima K, et al, J Clin Oncol 2007; 25:2798
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