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Pregnancy outcome
Pregnancy characteristics Control population
p-value
NS 10 (50.0) NS NS 1 (5.00) NS NS 2 (10.0) NS NS 7 (35.0) NS NS 36.4 ± 3.91 NS
p-value
Prenatal diagnosis indication
- Maternal age (n, %)
- Abnormal findings on ultrasound scan (n, %)
- Previous pregnancy with fetal anomaly (n, %)
- Maternal serum screening (2nd trimester) (n, %) Maternal age (years) (mean ± SD)
Chorionic villus sampling term (W A) (mean ± SD) Gestational age (W A) (mean ± SD)
(n = 198)
100 (50.5) 35 (17.7) 26 (13.1) 37 (18.7) 36.3 ± 5.44 14.4 ± 1.88 39.0 ± 2.14 21/191 (11.0)
31 (54.4) 5 (8.77)
4 (7.02) 17 (29.8) 36.1 ± 4.90 15.8 ± 2.99 38.3 ± 3.02 8/50 (16.0)
NS NS NS NS NS
p = 2.10-3 NS
21 (56.8) 4 (10.8)
2 (5.41) 10 (27.0) 35.9 ± 5.40 15.4 ± 2.36 39.5 ± 1.47 1/34 (2.94)
NS 16.7 ± 3.82 NS 35.7 ± 3.77 7/16 (43.7) 1 954 ± 875
13/16 (81.2) 9/16 (56.2) 10 (50.0) 4 (20.0)
p<10-4 p<10-4
Prematurity (n, %)
Birth weight (gr) (mean ± SD) Neonatal hypotrophy (n, %)
Severe neonatal hypotrophy (n, %) Sex (n, % boys)
Adverse pregnancy outcome (n, %) CPM = confined placental mosaicism;
W A = week of amenorrhea.
Type 2 and type 3 CPM
(n = 57)
3211±575 2823±894 3244±530
25/191 (13.1) 6/191 (3.14) 101 (51.0) 8 (4.04)
19/49 (38.8) 10/49 (20.4) 27 (47.4) 5 (8.77)
6/33 (18.2) 1/33 (3.03) 17 (45.9) 1 (2.70)
NS
p = 9.10-4 p<10-4 p<10-4 NS NS
NS NS NS NS NS NS
p<10-4 p<10-4 p<10-4 p<10-4 NS
p = 3.10-3
Type 3 CPM associated with prematurity, neonatal hypotrophy and IUFD
Type 2 CPM (n = 37)
p-value
Type 3 CPM (n = 20)
1
5000 4500 4000 3500 3000 2500 2000 1500 1000
Study #1 conclusion
Type 2 CPM (n = 33)
Type 3 CPM (n = 16)
Control population (n = 190)
500
25 27 29 31 33 35 37 39 41 43
Gestional age (weeks)
Toutain et al., Prenat Diagn 2010
54
PRECONGRESS COURSE 10 I VIENNA, AUSTRIA – 23 JUNE 2019 57
Birth weight (gr)