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Can mosaic embryos self-correct?
• Proposed self-correction mechanisms:
1. Aneuploid cells preferentially allocated to trophectoderm
2. Loss of extra chromosome or duplication of missing chromosome 3. Preferential growth of euploid cells
4. Preferential apoptosis of aneuploid cells
• No evidence for aneuploid cell distribution to TE
• No evidence for excess UPD frequency in mosaic embryos
Fragouli et al., 2008; Northrop et al., 2010; Capalbo et al., 2013; Spinella et al., 2018
Can mosaic embryos self-correct?
• Bolton et al., 2016 Murine data
1. Aneuploidy generated by exposure to reversine
Complex aneuploidy likely
Human complex mosaic embryos have lowest potential
2. Mosaic mouse embryos artificially constructed
Are self-correction mechanisms similar in human & mouse?
• Confirmatory studies in human embryos required
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