Page 100 - ESHRE2019

Outcome of mosaic embryo transfers
What are the outcomes for mosaic embryos transferred to the uterus
Embryos with mosaic trophectoderm samples associated with elevated miscarriage Maxwell et al., 2016 (Fertility & Sterility)
Age
Mosaic embryo implantation
Mosaic embryo ongoing pregnancy
Euploid
embryo implantation
Euploid embryo ongoing pregnancy
Greco et al., 2015
38%
-
-
Fragouli et al., 2017
30.1%
15.4%
55.8%
46.2%
Munne et al., 2017
41%
-
63%
-
What are the outcomes for embryos with different types of mosaicism?
Type cycles Implanted Lost Ongoing pregnancy
-----------------------------------------------------------------------------------------------------------
Mos. Complex
Mos. Double
Mos. Aneuploid
Mos. Segmental ----------------------------------------------------------------------------------------------------------
# Chromosomes 1 93 involved 2 29 ≥3 21
58 (62%) 15 (26%) 43 (46%)
16 (55%) 3 (19%) 13 (45%)
2 (10%) 0 (0%) 2 (10%) p<0.005
21 2 (10%) 29 16 (55%) 54 34 (63%) 39 24 (62%)
0 (0%) 3 (19%) 7 (21%) 8 (33%)
2 (10%) p<0.005 13 (45%)
27 (50%)
16 (41%)
Relevance of percentage of aneuploid cells not yet conclusively proven No difference between outcomes for monosomies and trisomies
95
98