Page 42 - ESHRE2019

Possible systemic causes of unexplained infertility ‐ Autoimmune antibodies (anti‐thyroid, anti‐ovarian, antinuclear, antiphospholipid and anti‐smooth muscle antibodie). Reduction of fertilisation rate, interference with early implantation and modulation of ovarian function. (Haller‐Kikkatalo K, Clin Dev Immunol 2012, Jefferys A The Obstetrician and Gynaecologist 2015) ‐ Thrombophilic gene polymorphisms: early implantation failure? (Casadei L, Fertil Steril 2010) ‐ Oxidative stress: imbalance between reactive oxygen species and antioxidants (obesity, smoking, alcohol, recreational drug use and environmental exposure). (Agarwal A, Reprod Biol Endocrinol 2012) Associated with female unexplained infertility, but the exact role and mechanism unclear No indications to routine screening in unexplained infertility Genetic and Genome‐wide analysis: we’re almost there 40 37