Page 14 - ESHRE2019

Prevalence of men’s infertility & help-seeking
From household-based UK study
Infertility defined: Tried to get pregnant for ≥12 months & did not get pregnant • Although infertility prevalence was slightly lower for males aged
16-24 (4%) & 25-24 (9%) vs. older ages • Help-seeking was quite low: 16-24 (14%) & 25-24 (50%)
.
35-44 14.9 (12.4-17.8)
Infertility
Help-seeking among infertile
% (95% CI) 53.2 (48.1–58.1)
56.9 (47.2–66.2)
Datta et al. Human Reproduction. 2016.
%
10.1 (9.2-11.1)
(95% CI)
.
All men
Age at interview
16-24 3.7 (2.6-5.1) 14.1 (6.8–27.1) 25-34 8.5 (7.0-10.2) 49.6 (40.1–59.1)
Conditions affecting male fertility
Many conditions place male children/youth at risk for infertility
• Young men may not be aware of conditions that occurred earlier in childhood • Many conditions may not present until adolescence
Iatrogenic
– Gonadotoxic chemotherapy
– Gonadotoxic radiation
Oncology, hematology, &/or immunology – Sickle cell disease
– Genitourinary surgery
– Genitourinary cancer
– Hemochromatosis
– Condition treated with...
 Chronic transfusions
 Stem cell transplantation Genetics / chromosomal
– Klinefelter syndrome
– Kallman syndrome
– Noonan syndrome
– Fragile X
– Absence of vas deferens
– Cystic fibrosis
– Galactosemia
– Down syndrome
Gastroenterology, cardiology, &/or pulmonary
– Inflammatory bowel disease
– End-stage liver disease
– End-stage cardiac disease
– End-stage lung disease
Urology &/or structural/anatomic – Hypospadias
– Varicocele
– Anorchia &/or testicular regression
– Disorders of sex development
– Bilateral cryptorchidism
– Prune Belly syndrome
– Bladder exstrophy-epispadias complex – Anorectal malformations
– Spinal cord injuries
– Spina bifida
– Cerebral palsy
Traumatic
– Testicular torsion
– Trauma
Rheumatology &/or nephrology
– Lupus &/or mixed connective tissue disease – Vasculitis
– Steroid-dependent nephrotic syndrome
– Rheumatoid arthritis
– End-stage renal disease
Endocrinology
– Diabetes mellitus
– Transgender
– Hypogonadotropic hypogonadism – Growth hormone deficiency
– Panhypopituitarism
– Hyperprolactinemia
– Thyroid dysfunction
Infectious
– Mumps orchitis
– HIV/AIDS
– STIs, epidydimitis
Illicit drug use
– Marijuana, cocaine, smoking
– Anabolic steroid abuse
* Some conditions may be associated with >1 category
Adapted from Dy et al. Urologic Nursing. 2012; Nehata et al. Pediatrics. 2018.
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