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Molecular microbiology vs hysteroscopy
• Diagnosis of CE by positive:
– HSC in 63/65 patients (96.92%)
– molecular microbiology in 38 cases (58%).
• Concordance was observed in 38 samples (37 double positives and 1 double negative) showing a matching accuracy of 58.46%.
• In 26 (96.29%) of 27 discordant patients, bacterial DNA was not identified in the paired endometrial sample obtained after positive hysteroscopic diagnosis of chronic endometritis.
• Interestingly, only 1 sample with no signs of CE in the HSC was
positive for Streptococcus species
?
(Moreno, Cicinelli et al., 2018)
• Hysteroscopy probably overextimates
• Not infectious endometritis
Results
Results of RT‐PCR were calculated using the endometrial samples with concordant HIS+HYS+Colt. diagnosis of CE as the gold standard:
• sensitivity (75%)
• specificity (100%)
• positive predictive values (100%)
• negative predictive values (25%)
• false positive rate (0%)
• false negative rate (25%)
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