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The primary endpoint is a composite of aPL related adverse pregnancy outcomes:
•Pregnancy loss < 10 weeks gestation
•Pregnancy loss > 10 weeks gestation
•Premature birth < 34 weeks due to any of: pre-eclampsia, eclampsia, fetal growth restriction & intrauterine death
Secondary endpoints:
•Gestational age at delivery •Birth weight
•Cesaerean delivery •Apgar score < 7 at 5 min •Neonatal morbidity
•Days to hospital discharge following delivery
•Thrombotic events in the mother during pregnancy and 6 weeks post partum
Endpoints
Inclusion criteria
• Women with known aPL (ie. isolated aPL or APS) who are actively planning pregnancy.
• Women will be started before conception
• aPL are defined by the presence of a positive test for aCL (IgG/IgM isotypes) and/or LAC and/or anti-beta 2 GP-I (IgG/IgM isotypes) twice more than 12 weeks apart
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