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Need for further omics approaches for biomarker discovery
High standards are required for performing omics biomarker discovery studies.
Standardization from sample collection to evaluation of omics data is essential.
There is a need for pre‐analytical and analytical transparency with „minimum information“ about all steps provided.
Potential biomarker models/algorithms have to be validated in independent group of patients and in multicenter studies.
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Pre‐analytical bias – requirement for standard operating procedures
„In routine clinical diagnostics as much as 60‐80% of errors occur in the pre‐ analytical phase.“
 „Differences in collection, processing and storage of biological materials can alter molecular composition and can influcence experimental outcomes, and thus can lead to irreproducible, misleading and erroneus results.“
 „Sensitive targeted and non‐targeted omics analyses can be jeopardized by the pre‐ analytical errors, due to low quality of samples.“
Standard operating procedures are needed to control and harmonize all pre‐analytical steps.
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