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Micro-RNA= short non coding regulatory RNAs
• First described: Ambros et al. 1993
• Gene expression regulators
o Expressed in all tissues
o Regulate a very wide spectrum of cellular processes o Estimated to influence translation of 30% of all genes
• Evolutionary very well conserved
• miRBAse 21 (latest version):
o 35828 miRNAs in 223 species o Homo sapiens: 2588 miRNAs
Biogenesis and working mechanisms of miRNA
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