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Exposure to ROS
H2O2, O2, OH
Health
• Aging
• Varicocele
• Infection
• Febrile illness
• Spinal cord injury
• Testicular cancer
• Testicular hyperthermia
• Immature spermatozoa
Lifestyle
• Smoking • Obesity
Exogenous
• Drug
• Chemotherapy • Radiation
• Pollution
• Centrifuge
• Storage
Overview
• Sperm chromatin structure
• Causes of sperm DNA damage
Tests for DNA fragmentation
• Tests for DNA damages
• Effects on IVF outcomes
• What can be done?
• Conclusions
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PRECONGRESS COURSE 01 I VIENNA, AUSTRIA – 23 JUNE 2019 95
