Page 22 - ESHRE2019

DNA strands can fragment in two ways
Single strand break Double strand break
ESHRE PCC Andrology, Vienna, 2019
SSB and DSB have different mechanisms of damage
SSB ‐ Oxidative Stress attack from outside DSB‐ dysfunction inside sperm
High impact during epididymal transit Topoisomerase or endonuclease dysfunction Mechanical stress on chromosomes
More toxic; irreparable by oocyte post fertilization
They cant be protected by antioxidant supplementation
ESHRE PCC Andrology, Vienna, 2019
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