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Other methods
• Zona pellucida selection
• Zeta potential
• Electrophorectic isolation
• Annexin V‐MACS
• Hyaluronic acid binding
• Motility (Zech‐selector)
P<0.05
14.2%
• Motile Sperm Organelle Morphology Examination (MSOME)
2.13%
While they enrich spermatozoa with less DNA damage, their efficacies on clinical outcomes are not proven.
Lancet, 2019
• Hyaluronan‐selectedspermhavereducedlevelsof DNA damage and aneuploidy
• SmallRCTsshowedimprovedembryoqualityandlive birth rates and reduced miscarriage age.
• 2772couplesrandomlyassignedtoreceive
– Hyaluronan‐selected sperm PICSI (n=1387) or ICSI
(n=1385)
• PICSIisnotsuperiortostandardICSIforimproving term livebirth rates, despite the reduction in miscarriage.
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PRECONGRESS COURSE 01 I VIENNA, AUSTRIA – 23 JUNE 2019 103
