Page 98 - Eshre 2018
P. 98
Hypothesis
on in vitro gametogenesis
Will rely on better understanding of
- germ cell segregation/establishment
- germ cell plasticity
- soma/germline interactions and communication - stem cell niche (clonal expansion)
Gamete production can be achieved by in vitro recapitulation of the gonadal microenvironment
- Female: embryonic/fetal stages of ovarian development
- Male: Adult seminiferous epithelium (Sertoli cells)
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