Page 94 - PCC10

Future Work
• Comparative data on mitochondrial health: OPC‐derived vs. aged oocyte
• Better quantification and correlation with outcome of mitochondria numbers placed in the oocyte
• Randomized‐blinded study:
– Straight randomization of oocytes vs. patients – Cross‐over design?
• A registry of children born from “Augment”
 Yale Laboratory of Molecular Reproduction & Fertility Preservation
– Kutluk Oktay, MD, PhD
– Shiny Titus, PhD
– Enes Taylan, MD
– Yodo Sugishita, MD, PhD
– Robert Stobezki, PhD
– Tai Kawahara, MD
– Giulia Cilo, MS

s
Pa
as
– Kutluk Oktay, MD, PhD
– Enes Taylan, MD
– Giuliano Bedoschi, MD
– Allison Rosen, PhD
– Ashley Cintron
P
st
H
D
F
D
,
Fe
B
,B
D
B
Y
D
Y
V
D
V
J
D
J
K
D
tF
He
h
ee
e
r
i
ir
o
o
ra
o
o
ha
Ky
V
D
V
y
u
o
o
Fe
es
rn
n
an
u
u
l
l
an
u
l
l
ns
n
n
k
ka
el
su
u
a
a
si
a
n
n
nM
n
nC
k
ka
a
ll
k
k
C
M
Ch
n
iR
g
ga
l
o
d
d
Re
a
ow
Ch
a
a
P
u
u
hu
nE
h
s
s
un
Em
ed
h
hJ
ws
dd
J
a
a
e
P
u
u
ng
m
e,
a
a
l
l
g,
i
ir
r
d
dy
e
eo
,
B.
y
on
,M
c
c
,M
d
,
,
M
ng
MD
h
he
M
a
a
.S
r
r
,
M
g,
D
K
ec
c
Sc
D
D
A
,
M
c
D
D
S
,M
,M
o
o,
.
MD
MD
,M
D
M
,M
D
I
M
D
P
E
Er
P
Sa
Il
ro
Ke
h
a
lg
g
ol
en
n
hD
u
ur
n
n
i
in
l
A
r
a
n
g
g
Ar
n
ny
at
h
T
Tu
rs
yR
tS
ho
ur
s
R
o
l
l
So
oo
r
k
a
an
od
o
on
k
c
n,
d
n
n
n
L
cu
,
M
r
ri
m
m
L
uo
MD
ig
e
g
og
e
u
ue
ez
ee
e
,
M
gl
z
e
l
ez
u
er
u,
z,
r
,
M
,
M
,M
M
D
MD
D
D,
Supported by R01 HD053112 and R21 HD061259
.
E
El
l
Ay
M
k
k
y
l
l
e
e
H
i
in
n
C
H
e
ey
Ci
il
yt
l,
te
en
,M
ns
MD
s,
,P
Ph
h
D
D
Extra‐Mural Collaborators:
 Sumanta Goswami, PhD,
(Yeshiva Univ/AECOM)
 Maura Dickler, MD & Mark Robson,MD, (Memorial Sloan Kettering Cancer Center)
Page 88 of 135
E
,M
D
En
O
,
ni
Oz
is
zg
s
O
g
u
O
ur
r
O
n
nT
z
z
T
k
ka
Ok
u
ur
ay
kt
t
ra
ya
e
a
a
em
n
n,
,
M
m
,
M
,
,
M
M
D
D
S
,M
MD
D
D
M
D
P
M
Si
P
i
a
ar
n
na
h
hD
r
g
ga
an
D
a
nO
l
li
i
Oz
d
da
z
k
aS
ka
a
S
v
v
u
a
as
s
uk
t
tr
k
r
i
c
c
i
,
,
M
u
u
,
MD
MD
D,
www.fertilitypreservation.org
Contact: info@fertilitypreservation.org
94