Page 80 - PCC08

DNA Damage, Ageing and Cancer
(Vermeij et al., Nature 2016)
Ovarian Phenotype in ERCC-1 Mice at 4 weeks
(Visser JA et al. Unpublished data, 2018)
200
180
160
140
120
100 wt
600 500 400 300 200 100
0
9 8 7 6 5 4 3 2 1
wt
Ercc1 d/-
80 60 40 20
Ercc1 d/-
***
large preantral
wt
Ercc1 d/-
00
small preantral large preantral small antral large antral small preantral
Page 74 of 102
small antral
large antral
80
number of follicles (healthy)
number of follicles (atretic)
number of primordial follicles