Page 78 - PCC08
P. 78

    DNA Damage, Ageing and Cancer
(Hoeijmakers JHJ, NEJM 2009)
            DNA Damage, Ageing and Cancer
(Hoeijmakers JHJ, NEJM 2009)
        The trichothiodystrophia (TTD) Phenotype
 premature ageing
 osteoporosis and kyphosis  osteosclerosis
 early greying
 cachexia
 infertility
 reduced life-span
TTD DNA repair defective mice are extremely sensitive to oxidative DNA damage.
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