Page 75 - PCC08

GWAS in POI
(Laven et al. Unpublished data 2018)
GWAS in POI: Most significant hits
(Laven et al. Unpublished data 2016)
Closest_gene
SNPID
chr
pos
Allele1
Allele2
Freq1
Effect
StdErr
P .value
Direction
HetISq
BRSK1 / TMEM150B
rs11668344
19
55833664
a
g
0.65
-0.439
0.041
3.07E-26
--
56.1
CRLS1 / MCM8
rs6139887
20
5986234
t
c
0.49
-0.221
0.040
2.72E-08
--
0
MIR2392 / DLK1
rs76240649
14
101271746
t
c
0.14
0.309
0.056
4.43E-08
++
0
CYP3A7
rs11568824
7
99333007
a
c
0.02
0.897
0.167
8.09E-08
++
0
RHBDL2
rs4246511
1
39380385
t
c
0.31
-0.235
0.044
1.09E-07
--
75.9
ZBED3
rs138566598
5
76409476
a
g
0.98
-0.786
0.149
1.37E-07
--
0
HERC1
rs75962830
15
64109599
a
g
0.03
0.671
0.132
3.75E-07
++
0
TMEM106A / BRCA1
17:41438953:I
17
41438953
d
i
0.74
0.240
0.048
7.60E-07
++
54.4
L3MBTL4
rs150724392
18
6345416
a
c
0.02
0.804
0.163
7.62E-07
++
76.9
FAF2
rs2241584
5
175956177
a
g
0.38
0.203
0.041
8.63E-07
++
0
TMEM14B
rs114977517
6
10755290
t
c
0.99
-0.901
0.183
8.77E-07
--
22.2
ERICH1-AS1
rs11783410
8
1027320
t
c
0.42
-0.199
0.040
8.80E-07
--
0
PRKCDBP
rs10839551
11
6341397
t
c
0.02
0.790
0.161
9.15E-07
++
0
EXD2 / GALNTL1
rs7160861
14
69742144
t
g
0.09
0.346
0.071
9.77E-07
++
25.8
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PRECONGRESS COURSE 08 I BARCELONA, SPAIN – 1 JULY 2018 75