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Genetic Variation and Age of Menopause
(Stolk et al., Nature Genetics, 2012; Repro-Gen & CHARGE cohorts unpublished data 2016)
GWAS data on 72.799 women form Reprogen and CHARGE cohorts and replication in 35.000 UKB samples In total data in 107.779 women
More than doubled number of signals
• 123 signals (60 new)
• 101 loci (58 new)
• Including 4 signals on X chromosome
Genetic Variation and Age of Menopause
(Stolk et al., Nature Genetics, 2012)
Mendelian randomisation showed evidence for causative relationship between menopause timing and:
• Osteoporosis
• Bone mineral density
• Uterine fibroids
• Breast cancer (BCACC)
• Ovarian cancer (BCACC)
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PRECONGRESS COURSE 08 I BARCELONA, SPAIN – 1 JULY 2018 73
