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Glucose metabolism
Inflammation
• Proteomics studies supporting this • Amjadi et a. 2018
Steroid Hormone effects
SE (Paulsen 2017)
Modified from Piltonen T, Best Practice & Research Clinical Obstetrics and Gynaecology, 2016
PCOS endometrium in ovulatory cycles
• Altered endometrial function in monkeys exposed to T and western style diet (WSD) • T and T+WSD treatment resulted in glands with
• less secretory morphology
• high ESR1 expression in the glandular epithelium
• low PGR in the stroma
• Low TIMP3 and MMP26
• No change in AR expression
Bishop et al., Hum Reprod 2018
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