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First Line Treatment: PCOS Infertility
5.3 Letrozole
5.3. Letrozole should be considered first line 1 pharmacological treatment for ovulation
induction in women with PCOS with anovulatory infertility and no other infertility factors to improve ovulation, pregnancy and live birth rates
Evidence Level
oo
4 Clomiphene citrate and Metformin
Evidence Level
4.2
4.4
Metformin in Infertility: PCOS
Metformin could be used alone in women with PCOS, with o anovulatory infertility and no other infertility factors, to improve
ovulation, pregnancy and live birth rates, although women should
be informed that there are more effective ovulation induction
agents
If metformin is being used for ovulation induction in women with oo PCOS who are obese (BMI ≥30kg/m2) with anovulatory infertility
and no other infertility factors, clomiphene citrate could be added
to improve ovulation, pregnancy and live birth rates
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