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Pregnancy Loss Rates in Women with PCOS is comparable to other Infertile Populations
Source
Indication
Pregnancy Loss in First Trimester
Additional Pregnancy Loss after U/S visualized IUP
PPCOSI (CC, Metformin,Combination)
PCOS
22-40% (Metformin = 40%)
3-5%
PPCOSII (CC,Letrozole)
PCOS
29-31%
1-2%
AMIGOS (CC,Letrozole, Gonadotropins)
Unexplained infertility
26-34%
1-3%
Diamond MP et al, NEJM, 2015 and Legro et al, NEJM 2007 &2014
Conclusions: With a little help from my friends
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