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Adverse Events During Treatment
 Significant differences between treatments
Event
Clomiphene Group
Letrozole Group
Hot flashes*
117 (33%)
73 (20%)
Fatigue*
53 (15%)
78 (22%)
Dizziness*
27 (8%)
44 (12%)
*P < .05
 Most common without difference between
treatments
1) Headache
2) Abdominal/ Pelvic Pain
3) Nausea
Legro et al, NEJM, 2014
Congenital Anomaly Rates in Two Large RCTs Conducted by the Reproductive Medicine Network
Indication
Clomiphene
Letrozole
Gonado- tropins
AMIGOS N = 900 Subjects
Unexplained infertility
4.2%
3.6%
3.2%
PPCOS II N = 750 Subjects
PCOS
1.9%
3.9%
Not Applicable
Diamond MP et al, NEJM, 2014and Legro et al, NEJM 2014
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