Page 101 - PCC07

Improved Fecundity with Letrozole per Subject who Ovulated
Outcome
Clomiphene group N=288 (%)
Letrozole group N=331 (%)
Rate ratio (95% CI)
Conception
103/288 (36)
154/331 (47)
1.31 (1.07 to 1.58)
Singleton pregnancy
75/288 (26)
113/331 (34)
1.31 (1.03 to 1.58)
Singleton live birth
67/288 (23)
99/331 (30)
1.29 (0.98 to 1.68)
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Legro et al, NEJM, 2014
Meta-Analyses of Letrozole in PCOS
 9 prospective RCTs comparing the use of letrozole to CC in PCOS patients
 The birth rate was higher in the letrozole group (OR 1.63, 95% CI 1.31 to 2.03, n=1783, I2=3%)
Franik et al, Cochrane Database Syst Rev. 2014
 There were no differences in the multiple pregnancy, and miscarriage rates between the two groups.
Roque et al, Gynecol Endocrinol, 2015
PRECONGRESS COURSE 07 I BARCELONA, SPAIN – 1 JULY 2018 101