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Recent meta analysis 5 x RCTs (2013-2017)
‘Use of Time-lapse information to evaluate embryos improves outcomes’.
Favors control Favors time-lapse
(OR: 1.56; CI = 1.30–1.88; P < 0.001; based on 1945 cases, intention-to-treat analysis;
Pribenszky, C., Nilselid, A-M, Montag, M.,RBM online, March 2018 Volume 36, Issue 3, Pages 290–292
Meta analysis – overview of data
60%
51% 50%
40% 30% 20% 10%
0%
40%
Ongoing pregnancy
OR 1,542; CI 1,211-1,965; p <0,001
44%
41%
Live Birth
Time-lapse
28% Standard Evaluation
relative difference
27%
31%
21%
Early pregnancy loss
OR 1,668; CI 1,134-2,455; OR 0,662; CI 0,469-0,935; p 0,009 p 0,019
Csaba Pribenszky, Anna-Maria Nilselid, Markus Montag (2017) Time-lapse culture with morphokinetic embryo selection improves
Issue 5, p511–520
1
pregnancy and live birth chances and reduces early pregnancy loss: a meta-analysis Reproductive BioMedicine Online, Vol. 35,
15%
0
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