Page 95 - PCC02

Time lapse v conventional - consistency
Sig. higher PR in TL compared with their standard methods– all ages
Sig. lower loss rate in TL
1600 patients
TLI
High alignment in choice of embryo on Day 5 with time- lapse, compared with standard methods
Gwet value
Conventional
Time lapse
CMA
No alignment
Martinez et al., PLOS One 2017;25:12
Complete alignment
0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1
Improved objectivity: Quality assurance
Interobserver and intraobserver agreement for assessed parameters
Parameter
Inter ICC
N
95% CI
PN appearance
PN abuttal
PN breakdown
First cytokines
1st nuclei appearance 2nd nuclei appearance 1st nuclei disappearance 2nd nuclei disappearance 1st cleavage division
2nd cleavage division 3rd cleavage division 4th cleavage division 5th cleavage division 6th cleavage division 7th cleavage division Final division Compaction
Morula
Early blastocyst
Full expanded blastocyst Hatching blastocyst Hatched blastocyst Blastocoel contractions
ICC, intra-class correlation coefficient; PN, pronuclei.
0.678 113 0.568–0.764
0.773 90 0.999 130 0.92 138 0.984 90 0.967 78 0.989 86 0.75 75 0.958 134 0.885 133 0.809 141 0.863 125 0.868 123 0.906 99 0.9 68 0.599 82 0.686 114 0.737 111 0.894 114 0.913 116 0.872 75 0.99 11 0.653 75
0.692–0.838 0.998–0.999 0.895–0.94 0.977–0.989 0.953–0.978 0.985–0.993 0.66–0.824 0.945–0.969 0.85–0.913 0.756–0.853 0.821–0.897 0.826–0.901 0.872–0.933 0.852–0.935 0.336–0.757 0.581–0.769 0.642–0.81 0.8–0.939 0.869–0.941 0.816–0.914 0.972–0.997 0.536–0.752
Sundvall L, et al. Hum Reprod. 2013;28:3215-21.
Page 89 of 151
PRECONGRESS COURSE 02 I BARCELONA, SPAIN – 1 JULY 2018 95