Page 79 - PCC02

Fertilization competence - The theory -
Normal Activation Competence
Optimal fertilization window
Spontaneus Activation Events:
MPF
MAPK
Ana II
CG Exocytosis New Proteins
Mouse
-24 -12 0 12 24
Hrs -/+ Ovulation
Human
0 20 38 50 62
GV Meta I Meta II Ana II
Hrs post hCG
Meiotic Stage
• Almost 1500 ICSI cycles assessed
• Precisely collected times of • Pick up (OPU)
• Denudation (DEN)
• ICSI
• Different intervals analysed • OPU‐DEN (partial)
• DEN‐ICSI (partial)
• OPU‐ICSI (total)
• Logistic regression applied to adjust for several factors Pujol et al., 2018
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PRECONGRESS COURSE 02 I BARCELONA, SPAIN – 1 JULY 2018 79