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The evolution of software analysis in TL:V1.0
Phase 1 Retrospective
Phase 2 Prospective
Phase 3 Prospective Automatic
More observation s Better selection
274 cycles
120 cycles
3,781 analysed embryos
> 409 analysed embryos
> 190 analysed embryos
1,676 transferred embryos
389 transferred embryos
147 transferred embryos
1,021 KID embryos
261 KID embryos
110 KID embryos
Slide courtesy of Marcus Meseguer, IVI RMA
Alegre L, et al. Fertil Steril. 2017;108:e239 (P-347).
799 cycles
Conclusions –
Time lapse today and tomorrow
 A lot has happened in a decade & our knowledge is enhanced  Time lapse brings benefits for patients and clinics
 Data generation is vast
 Automated assessment and use of AI is likely
Simple approaches....... Artifical intelligence and beyond
1. Precise morphology - avoid timing delays and omissions 2. Device integrated software
3. ‘Man made’ algorithms
4. Artificial intelligence
Undisturbed incubation
Flexible workflow
Avoid missing events
Easy to use
Support from manufacture r
May improve outcomes compared with standard
Machine based learning
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