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Testis
DSD gonad
GCNIS
OCT3/4
Gonadoblastoma
Invasive components
Precursors testis/DSD gonad (gonadoblastoma)
Hersmus et al. , 2009
GCNIS, SOX9+ [FOXL2-] GB, FOXL2+ [SOX9-]
Histology precursor due to level of testicularization
OCT3/4 and SCF (KITLG): Distinction between delayed matured and (pre-)GCNIS -- versus ++
Diagnosis based on (gonadal) tissue analysis
Diagnosis earliest (pre-)malignant cell
Stoop et al., 2008
delayed maturation: (OCT3/4+/ KITLG-)
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PRECONGRESS COURSE 01 I BARCELONA, SPAIN – 1 JULY 2018 53
