Page 51 - Eshre 2018

Overview pathology GCNIS related TGCT.
PRE-INVASIVE:
OCT3/4
GCNIS (GB-DSD)
Early gonadal development
COMMON PRECURSOR
Blocked PGC/gonocyte (EMBRYONIC GERM CELL)
INTRATUBULAR:
seminoma embr. carc.
OCT3/4 OCT3/4
70%
~ 7 years
INVASIVE:
OCT3/4
seminoma
OCT3/4
embr.carc.
teratoma
PLURIPOTENT (TOTI-/OMNI-)
Palumbo et al., 2001; Looijenga et al., 2003, De Jong et al., 2005, Cheng et al., 2006; De Jong and Looijenga, 2007, Van Casteren et al., 2008a,b, 2009, De Jong et al., 2008, Nonaka et al., 2009, Sonne et al, 2010, Gillis et al., 2011, Ushida et al., 2012, Eini et al., 2014, and many others.
yolk sac tum.
germ cells
choriocarc.
Overview pathology GCNIS related TGCT.
OCCTT33//44
PRE-INVASIVE: SOX17 GCNIS (GB-DSD)
COMMON PRECURSOR
Early gonadal development
Blocked PGC/gonocyte (EMBRYONIC GERM CELL)
INTRATUBULAR:
seminoma
OCCTT33//44
SOX17
embr. carc.
OCCTT33//44
SOX2
70%
~ 7 years
INVASIVE:
OCCTT33//44
SOX17
seminoma
OCCTT33//44
SOX2
embr.carc.
SOX2
teratoma
SOX17
PLURIPOTENT (TOTI-/OMNI-)
germ cells
Palumbo et al., 2001; Looijenga et al., 2003, De Jong et al., 2005, Cheng et al., 2006; De Jong and Looijenga, 2007, Van Casteren et al., 2008a,b, 2009, De Jong et al., 2008, Nonaka et al., 2009, Sonne et al, 2010, Gillis et al., 2011, Ushida et al., 2012, Eini et al., 2014, and many others.
yolk sac tum.
choriocarc.
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PRECONGRESS COURSE 01 I BARCELONA, SPAIN – 1 JULY 2018 51