Page 90 - PRECONGRESS COURSE 06

Earlier antagonist initiation Hypothesis
Prevention of high LH levels during the follicular phase may improve
endometrial receptivity and pregnancy rates Kolibianakis et al., 2003; Bosch 2003; Huirne et al.; 2005 Seow 2010; Shoham 2002
Both high estradiol and progesterone levels have been associated with impaired endometrial receptivity
and oocyte/embryo quality
Bosch et al. ; 2003, Kyrou et al., 2011, 2012
May moderate ovarian response and reduce the risk of
ovarian hyperstimulation syndrome (OHSS) Hamdine et al., 2013
Day 4 Vs Day 5 Vs Day 6
Significant higher ongoing pregnancy rate D4 and D5 respect to D6
Significant less COCs D4 and D5 respect to D6 (n=208)
D5 (OR 2.74 95% CI 1.33–5.65), D4 (OR 3.09 95% CI 1.29–7.31)
Lainas et al. 2005
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