Page 45 - PRECONGRESS COURSE 06

Oocyte number and embryo implantation
IVF outcome in high responders by oestradiol concentration
≤1700 pg/ml
>1700 pg/ ml
Number of oocytes
21.9 ± 8.1
26.2 ± 10.2
Progesterone on day of hCG ng/ml
0.6 ± 0.4
0.9 ± 0.7
Implantation rate (%)
6/49 (12.2)*
8/209 (3.8)
Pregnancies (%)
5/11 (45.5)*
5/52 (9.6)
* Significant difference Simon et al., Hum Reprod 1995
Ovarian stimulation and embryo aneuploidy?
• Prospective cohort study
• Egg donors aged < 35years undergoing unstimulated and subsequent stimulated IVF
Number of biopsied embryos
Number of informative embryos
Blastomeres on day 3
Fragmentation on day 3
Chromosomally normal embryos/ informative embryos
Chromosomally normal embryos/ informative embryos
Blastocysts on day 5/ biopsied embryo
Unstimulated cycle
46
46
7.4±1.4
7.4±6.2
16/46 (34.8%)
16/46 (34.8%)
31/46 (67.4%)
Stimulated cycle
307
303
7.9±0.9
9.1±4.7
123/303 (40.6%)
123/307 (38.2%)
238/307 (77.5%)
P value
0.07
0.13
0.45
0.64
0.13
Labarta et al., J Clin Endocrinol Metab 2012
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PRECONGRESS COURSE 06 I GENEVA, SWITZERLAND – 2 JULY 2017 45