Page 32 - PRECONGRESS COURSE 06

Gonadotropin, AMH, AFC & FSHR and FSHβ SNP’s
(La Marca et al., Human Reprod, 2013)
FSH β 211 G/T
FSHR 2039 A>G
FSH β 211 G/T
FSH β 211 GG FSH β 211 GT/TT
FSHR 2039 A>G
FSH β 211 GG FSH β 211 GT/TT
Key Points 3
 Several SNP’s in the FSH Receptor do have some functional effects on FSH and LH serum levels
 The least sensitive FSH Receptor is associated with higher endogenous FSH levels and with a longer
follicular phase length and hence with longer menstrual cycle length
 The least sensitive FSH receptor is also associated with an increased number of antral follicles
 FSH-β chain SNP’s are also associated with differences in FSH serum levels
 FSH-β chain SNP’s have a different distribution amongst different groups of infertile women
 FSH-β chain SNP’s are also associated with differences in AFC and AMH serum levels
 FSH-β chain SNP’s are associated with time to pregnancy
 FSH Receptor as well as FSH-β chain SNP’s seem to enhance each other effects in case the least frequent alleles are appearing together
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