Results – All cases Cumulative LBR – 18 months Individualized N=746 Standard N=765 Relative Risk (95% CI) P-value LBR, n(%) 56.3% 58.0% 1.00 (0.90- 1.10) 0.98 Time to LB 154 days 144 days 0.62 CEA Bootstrapping 238 Page 234 of 258