Page 237 - PRECONGRESS COURSE 06

Ovarian Reserve markers based Personalised COS - RCT design -2
Individualised Dosing: Using Basal FSH, BMI, age and AFC
•Less Oocytes
•Less FSH used
•Same fresh Lbrates/cycle
Reduced OHSS?
Improved Cost Efficiency??
Olivennes, RBM 2015
GONAL-f ® CONSORT Calculator
GONAL-f ®
Standard Treatment 150
Number of Participants
96
104
Age (Yrs)
30.0 ± 2.9
30.6 ± 2.6
Not diff
Serum Anti- Mullerian Hormone (AMH)
2.7 ± 1.870
2.4 ± 1.492
Not diff
Serum Progesterone (P4)
2.934 ± 2.328
2.803 ± 2.291
Not diff
Number of Oocytes Retrieved
10 ± 5
12 ± 5
P = 0.037
Daily GONAL-f® Dose (U)
120 ± 22
170 ± 31
P = 0.0001
Cancel Poor Response
9
5
No p level
Cancel Excessive Response
1
6
No p level
Live Birth Rate
28.5%
27.3%
P = 0.6
Participants With OHSS
6
13
No p level
The OPTIMIST trial - NTR2657
InIn standard
Cycle 2,3...
AFC 0-7
RCT 1
AFC5
RCT 2 AMH
Indarivmid:uDaolised
Cycle 2,3...
aramd:juDsotsmeents
Cycle 2,3...
dpjuesrmtmitetendts.
Elecsys
5 Broekmans et al. FS 2011
AFC 8-10
AFC 11-15
AFC >15
N=1530
18 months / Live Birth
FSH 450 IU
FSH 150 IU
FSH 225 IU
FSH 150 IU
Cycle 2,3...
pePrmooitrteodr in HyHpyeprer
ReRsepsopnosnes:e:
FSH 150 IU
Cycle 2,3...
FSH 100 IU
Cycle 2,3...
WWithitmhamxa2x550
FSH 150 IU
a
Cycle 2,3...
IUIU↓↓oror↑↑
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PRECONGRESS COURSE 06 I GENEVA, SWITZERLAND – 2 JULY 2017 237