Page 222 - PRECONGRESS COURSE 06

Duration of progesterone administration
 Cleavage stage embryo:
Clinical pregnancy
Per started cycle
Per embryo transfer
Early pregnancy loss
Group A
3 days progesterone
26/150 (17.3%)
26/138 (18.8%)
32/58 (55.2%)
Group B
5 days progesterone
37/150 (24.7%)
37/137 (27.0%)
21/58 (36.2%)
Odds ratio (CI)
1.6 (0.89-2.74)
1.6 (0.90-2.82)
0.46 (0.22-0.97)
p-value
0.12
0.11
0.04
van de Vijver et al, Hum Reprod., 2016
Duration of progesterone administration
 Early pregnancy loss:
 embryonic/foetal chromosomal abnormalities
 Quenby et al, 2002; Vanneste et al, 2009
 implantation beyond the normal period of
endometrial receptivity  Wilcox et al, 1999
 a prolonged window of endometrial receptivity may account for delayed implantation of severely compromised embryos and subsequent early
pregnancy loss  Salker et al, 2010
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