Page 201 - PRECONGRESS COURSE 06

GnRH agonist triggering for final oocyte maturation: Research prospective Optimization of the luteal phase support
Although stimulation of corpora lutea with LH activity
is a feasible task and an extremely interesting research field,
the aim of achieving pregnancy in a high risk for OHSS patients
is not relevant to the initial rationale for replacing hCG with GnRH agonist, which was the avoidance of severe OHSS
Supplementation of the luteal phase after GnRH agonist triggering with the aim to sustain the probability of pregnancy after fresh transfer might be risky due to the occurrence of either early or even late OHSS
Conclusions
Severe OHSS is always present after triggering of final oocyte maturation with hCG, to a variable extent,
depending on the baseline risk of the population analysed
Since with the use of GnRH agonist triggering,
the endogenous elicited LH lasts for only 24-36 h
sustained stimulation of corpora lutea by the circulating for 10 days hCG levels is avoided
In this way, triggering of final oocyte maturation with GnRH agonist
has the potential to decrease the occurrence of severe OHSS as compared to hCG
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PRECONGRESS COURSE 06 I GENEVA, SWITZERLAND – 2 JULY 2017 201