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In vitro activation or natural resumption of ovarian function?
25,00% 20,00% 15,00% 10,00%
5,00% 0,00%
IVA vs spontaneous resumption of ovarian function
DELIVERY LIVEBORN Spontaneous delivery
FOLLICULAR GROWTH/ MENSES RESUMPION In vitro activation
Suzuki et al, Hum Reprod 2015 Bidet et al., JCEM 2011
Conclusions
 Prognosis in poor responders is always poor
 Ovarian stimulation has limited effect and only when follicles exist
 Future research should focus on increasing the recruitable follicular pool
 Testosterone or in vitro activation of primordial follicles appear promising
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