Page 168 - PRECONGRESS COURSE 06

Activation of primordial follicles
The PTEN inhibition and activation of primordial follicles (PI3K pathway)
FSH levels
Inhibition of PTEN and activation of PI3K in mice
 Ovariectomy
 Incubation of ovaries with bpV(pic)- PTEN inhibitor
740Y-P – stimulates PI3K
Reddy et al, Science 2008
 Auto-transplantation
Li et al., PNAS 2010
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