Page 155 - PRECONGRESS COURSE 06

What is the aetiology poor response ?
c
Turner syndrome FMR1 premutation
G
G
e
e
n
n
e
A
Ag
g
e
e
et
t
i
i
c
I
Low ovarian reserve
I
c
a
a
t
tr
ro
o
g
g
e
en
n
i
ic
Ovarian surgery Gonadotoxic therapy
(chemo/radio)
ne eU
Autoimmune oophoritis
PGA I,II (adrenal autoimmunity coexistent)
A
Au
ut
to
o
i
i
m
m
m
m
u
u
n
U
n
nk
kn
no
o
w
w
n
n
In vitro fertilization vs Intrauterine insemination
 Male factor involvement
 Duration of infertility
 Patient age
Time to menopause according to ovarian reserve
 Severity of poor response
AMH quartiles
HR for menopause
<0.20
0.20–0.70
0.70–1.50 1.97 >1.50 1.00
P value
<0.0001 <0.0001 0.008
(ng/ml)
4.85 3.37
Forty over treatment trial (FORT-T) Goldman et al., Fertil Steril 2014
Freeman et al., JCEM 2012
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PRECONGRESS COURSE 06 I GENEVA, SWITZERLAND – 2 JULY 2017 155