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Learning objectives
 Definiton of the poor ovarian responder
 Aetiology of poor ovarian response
 Deciding whether IVF/ICSI is preferable over IUI
 Comparison of stimulation protocols for poor responders
• Type of analogue used
• Type of gonadotropin used
• High FSH doses
• Dual stimulation
• Accumulation of oocytes
• Natural cycle IVF
 Exploring the role of testosterone in the treatment of poor responders
 Evaluating the potential use of vitro activation (IVA) of dormant follicles in the future
Do we really know who are the poor ovarian responders ?
 47 randomized trials using 41 definitions for poor ovarian responders  No more than 3 trials used the same definition
 Even trials from the same research group used different definitions
Polyzos and Devroey, Fertil Steril 2011
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