Page 141 - PRECONGRESS COURSE 06

Ovarian Reserve markers based Personalised COS - RCT design -1
In cases with normal basal FSH, an individual stimulation dose, based on a model with AFC, ovarian volume, ovarian flow, female age and smoking resulted in reduced poor response rate and higher pregnancy rates compared to a standard dose (n=262)
Popovic-Todorovic B, et al. Hum Reprod 2003
Ovarian Reserve markers based Personalised COS - RCT design -2
Individualised Dosing: Using Basal FSH, BMI, age and AFC
• Less Oocytes
• Less FSH used
• Same fresh Lbrates/cycle
Reduced OHSS?
Improved Cost Efficiency??
Olivennes, RBM 2015
GONAL-f ® CONSORT Calculator
GONAL-f ®
Standard Treatment 150
Number of Participants
96
104
Age (Yrs)
30.0 ± 2.9
30.6 ± 2.6
Not diff
Serum Anti- Mullerian Hormone (AMH)
2.7 ± 1.870
2.4 ± 1.492
Not diff
Serum Progesterone (P4)
2.934 ± 2.328
2.803 ± 2.291
Not diff
Number of Oocytes Retrieved
10 ± 5
12 ± 5
P = 0.037
Daily GONAL-f® Dose (U)
120 ± 22
170 ± 31
P = 0.0001
Cancel Poor Response
9
5
No p level
Cancel Excessive Response
1
6
No p level
Live Birth Rate
28.5%
27.3%
P = 0.6
Participants With OHSS
6
13
No p level
Page 137 of 258
PRECONGRESS COURSE 06 I GENEVA, SWITZERLAND – 2 JULY 2017 141