Page 124 - PRECONGRESS COURSE 06

GnRHa trigger – development of protocol
• First trials low clinical pregnancy rate – high early pregnancy loss
(Humaidan et al., 2005; Kolibianakis et al., 2005) Additional studies in:
• Follicular fluid
(Yding Andersen et al., Hum Reprod 2006)
• FER live birth after GnRHa versus hCG triggering (Griesinger et al., Fertil Steril 2007)
• Amphiregulin levels in follicular fluid after GnRHa triggering, hCG triggering and in natural cycle
(Humaidan et al., Fertil Steril 2011)
Luteal phase insufficency caused by low LH
Early Luteal Phase After GnRHa Triggering
17
GnRHa OPU
LH
28-32 hours
hCG
1.500 IU HCG
Day 8
LH activity deficiency period
; Bonduelle et al., 1988; Gonen et al., 1990; Itskovitz et al., 1991; Humaidan et al., 2006
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