Page 50 - PRECONGRESS COURSE 04

Regulation of the receptive phase
University Hospital Essen - Prof. Dr. Ruth Grümmer
implantation‐ competent blastocyst
embryo‐maternal interaction
receptive endometrium
ESHRE 2017 - Geneva
E2 P4
Why translational models are needed?
implantation
% 100 80 60 40 20 0
100 100
treat1ment cycles
86 86
em2 bryo transfer
29 29
p3reg- nancy
21
4live birth
Impairment of:
•embryo developmental potential •endometrial receptivity •embryo‐uterine dialogue
German IVF register 2015
 high rate of implantation failure
 pathophysiology still not fully understood
 studies in humans are limited by ethical considerations
University Hospital Essen - Prof. Dr. Ruth Grümmer
ESHRE 2017 - Geneva
50