Page 149 - PRECONGRESS COURSE 04

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• Cell therapy using autologous peripheral blood CD133+ BMDSC offer a safe and efficient therapeutic approach for patients with refractory AS and/or (EA) wishing to conceive.
• Our primary objective was the reconstruction of the endometrium which occurred in 15 out of 16 patients assessed by histeroscopy, histology and US. Mature vessel density increased as well as duration and intensity of menses returning to the initial levels 6 months after the treatment.
• The secondary objective was the functionality of the newly formed endometrium by attempting to conceive. Several pregnancies were achieved spontaneously and through ART after cell therapy. We have 5 babies born. Nevertheless, conception success remains to be improved.
• The injection of human SPIOs labeled CD133+ BMDSCs in a murine model of AS confirms that these cells engraft around endometrial vessels, at low rates (0,60% of injected cells) inducing proliferation of surrounding cells through paracrine molecules such as thrombospondin 1 and insulin-like growth factor 1.
Senior Researchers
Felipe Vilella, PhD (Lab.Director)
Xavi Santamaria, MD, PhD (Medical Director) Inmaculada Moreno, PhD (Lab Manager) Diana Valbuena (Medical Manager)
Tamara Garrido, PhD
Aymara Mas, PhD
Carlos Simon Laboratory
Former Researchers
Jose Vicente Medrano, PhD Francisco Dominguez, PhD Irene Cervelló, PhD
Patricia Diaz, PhD
Collaborators
Lab. Technicians
Maria Herrero Marta Gonzalez Patricia Escorcia
Bioinformatics
Jorge Jimenez, PhD Roser
Mónica Clemente, PhD Roberto
Davide Baù, PhD
PhD Students
Maria Vera Nuria Balaguer Alessia Grasso Jose M. Miguez Silvia Perez David Bolumar Irene Corachan
Navarro PhD Alonso PhD
Renee Reijo Pera Montana University USA
Steve Quake Stanford University, USA
Susan Fisher UCSF USA
Ayman Al-Hendy. Georgia Regents University USA Vittorio Sebastiano. Stanford University, USA
Kyle Orwig. Pittsburgh University, USA
Funding
EC FP7-PEOPLE-2012-IAPP grant SARM, No. 324509.
EC Eurostars-Eureka Programme, No. E!6478-NOTED
Spanish Ministry of Science and Innovation (SAF 2008-02048 & SAF 2012-31017), Spanish Ministry of Health (EC11-299 & RD06/0010/1006 & FIS-PI13/00546) and Regional Valencian Ministry of Education (PROMETEO/2008/163 & PROMETEOII/2013/018). KY Cha Award in Stem Cell Technology.
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