Page 11 - PRECONGRESS COURSE 04

Normal endometrial function
• Unopposed oestrogen (E) exposure promotes regeneration and proliferation post-menses
• E induces expression of ER & PR
• Period of unopposed E exposure essential for up-regulation of PR. The endometrium responds to progesterone (P) in luteal phase - differentiation
• P essential for establishment of pregnancy following a period of unopposed E exposure.
• PR (progesterone receptor) plays essential role in uterine physiology and reproduction.
Menstrual cycle stage (governed by endocrine/steroid environment) has major impact on endometrial form and function
Healing Restoration
angiogenesis
regeneration
P
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Differentiation Inflammation
Hypoxia Shedding
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PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 11