Page 90 - PRECONGRESS COURSE 03
P. 90
Ultimate test of the Chromosomal Aging hypothesis
Establish and maintain chromosome configurations?
DNA recombination rates ‘steady’ with age Univalents should increase with age
The ‘good side’ of DNA damage
• Programmed double-strand break formation in oocytes & sperm, which gives rise to ‘recombination’.
• Chromosome recombination mediates their accurate segregation at meiosis I in gametes.
• Chromosome errors in segregation lead to aneuploidy (extra or missing chromosomes).
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