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J curve in oocytes and preimplantation embryos
% affected
Preimplantation embryos
Natural population
(clinical pregnancies)
(Hassold and Hunt, Nat Rev Genet, 2001) (Franasiak et al., Fert Ste, 2012)
Maternal age
Age-related component of aneuploidy
S
Chaotic (arrest?)
PLK4, TUBB8
Recombination & cohesion
Error-prone spindles
Bivalent chromosomes
Meiotic Mitotic
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PRECONGRESS COURSE 03 I GENEVA, SWITZERLAND – 2 JULY 2017 79
