Page 77 - PRECONGRESS COURSE 03
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Learning objectives
• DNA damage occurs endogenously in oocytes and embryos.
• There are different types of DNA damage.
• Some DNA is serves important functions; others causes ‘aging’ and ovarian dysfunction
• Loss of chromosome structure and integrity may cause aneuploidy in women
• DNA damage and chromosome instability in embryos restrict their developmental potential.
The DNA damage response promotes genome integrity
DNAdamageresponse (DDR)
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PRECONGRESS COURSE 03 I GENEVA, SWITZERLAND – 2 JULY 2017 77
